The In Vivo Biology of the Mitochondrial Calcium Uniporter.

TitleThe In Vivo Biology of the Mitochondrial Calcium Uniporter.
Publication TypeJournal Article
Year of Publication2017
AuthorsLiu, JC, Parks, RJ, Liu, J, Stares, J, Rovira, II, Murphy, E, Finkel, T
JournalAdv Exp Med Biol
Volume982
Pagination49-63
Date Published2017
ISSN0065-2598
KeywordsAdenosine Triphosphate, Animals, Calcium, Calcium Channels, Calcium Signaling, Calcium-Binding Proteins, Cation Transport Proteins, Cell Death, Energy Metabolism, Genotype, Humans, Mice, Knockout, Mitochondria, Mitochondrial Membrane Transport Proteins, Phenotype, Protein Conformation, Structure-Activity Relationship
Abstract

The identification of the molecular composition of the mitochondrial calcium uniporter has allowed for the genetic manipulation of its components and the creation of various in vivo genetic models. Here, we review the initial attempts to modulate the expression of components of the calcium uniporter in a range of organisms from plants to mammals. This analysis has confirmed the strict requirement for the uniporter for in vivo mitochondrial calcium uptake and for maintaining mitochondrial calcium homeostasis. We further discuss the physiological effects following genetic manipulation of the uniporter on tissue bioenergetics and the threshold for cell death. Finally, we analyze the limited information regarding the role of various uniporter components in human disease.

DOI10.1007/978-3-319-55330-6_3
Alternate JournalAdv. Exp. Med. Biol.
Citation Key10.1007/978-3-319-55330-6_3
PubMed ID28551781