Mitochondrial DNA mutations in neurodegeneration.

TitleMitochondrial DNA mutations in neurodegeneration.
Publication TypeJournal Article
Year of Publication2015
AuthorsKeogh, MJ, Chinnery, PF
JournalBiochim Biophys Acta
Volume1847
Issue11
Pagination1401-11
Date Published2015 Nov
ISSN0006-3002
KeywordsAdenosine Triphosphate, Alzheimer Disease, Animals, DNA, Mitochondrial, Humans, Lewy Body Disease, Mutation, Neurodegenerative Diseases, Stroke
Abstract

Mitochondrial dysfunction is observed in both the aging brain, and as a core feature of several neurodegenerative diseases. A central mechanism mediating this dysfunction is acquired molecular damage to mitochondrial DNA (mtDNA). In addition, inherited stable mtDNA variation (mitochondrial haplogroups), and inherited low level variants (heteroplasmy) have also been associated with the development of neurodegenerative disease and premature neural aging respectively. Herein we review the evidence for both inherited and acquired mtDNA mutations contributing to neural aging and neurodegenerative disease. This article is part of a Special Issue entitled: Mitochondrial Dysfunction in Aging.

DOI10.1016/j.bbabio.2015.05.015
Alternate JournalBiochim. Biophys. Acta
Citation Key10.1016/j.bbabio.2015.05.015
PubMed ID26014345
Grant List103396/Z/13/Z / / Wellcome Trust / United Kingdom
101876 / / Wellcome Trust / United Kingdom
MC_UP_1501/2 / / Medical Research Council / United Kingdom
096919Z/11/Z / / Wellcome Trust / United Kingdom
G0601943 / / Medical Research Council / United Kingdom