Twenty-four-hour urinary thiamine as a biomarker for the assessment of thiamine intake.

TitleTwenty-four-hour urinary thiamine as a biomarker for the assessment of thiamine intake.
Publication TypeJournal Article
Year of Publication2008
AuthorsTasevska, N, Runswick, SA, McTaggart, A, Bingham, SA
JournalEur J Clin Nutr
Volume62
Issue9
Pagination1139-47
Date Published2008 Sep
ISSN0954-3007
KeywordsAdult, Aged, Biomarkers, Diet, Diet Records, Female, Food Analysis, Humans, Male, Middle Aged, Nutrition Assessment, Thiamine, Young Adult
Abstract

OBJECTIVE: To investigate 24-h urinary thiamine as a potential biomarker for thiamine intake for use in validation studies to assess the validity of dietary intake data collected by self-reporting dietary methods.SUBJECTS: Seven male and six female healthy participants living for 30 days in a metabolic suite under strictly controlled conditions consuming their usual diet as assessed beforehand from four consecutive 7-day food diaries kept at home. During the 30-day study, all 24-h urine specimens were collected, validated for their completeness and analysed for thiamine.RESULTS: Thirty-day mean (+/-s.d.) calculated thiamine intake was 2.22+/-0.55 mg/day. Thirty-day mean (+/-s.d.) urinary excretion of thiamine was 526.5+/-193.0 microg/day (24.7+/-8.10% of intake). There was a highly significant correlation between individuals' 30-day means of thiamine intake and their mean excretion level (r=0.720; P=0.006), where 1 mg of thiamine intake predicted 268.2 microg of thiamine in urine. The correlations between intake and excretion remained significant when measurement from a single 24-h urine collection was used (r=0.56).CONCLUSION: Twenty-four-hour urinary thiamine can be used as a concentration biomarker for thiamine intake in dietary validation studies.

DOI10.1038/sj.ejcn.1602829
Alternate JournalEur J Clin Nutr
Citation Key10.1038/sj.ejcn.1602829
PubMed ID17565356
Grant List / / Medical Research Council / United Kingdom