Targeting lipophilic cations to mitochondria.

TitleTargeting lipophilic cations to mitochondria.
Publication TypeJournal Article
Year of Publication2008
AuthorsMurphy, MP
JournalBiochim Biophys Acta
Volume1777
Issue7-8
Pagination1028-31
Date Published2008 Jul-Aug
ISSN0006-3002
KeywordsAdenosine Triphosphate, Antioxidants, Cations, Cell Physiological Phenomena, Cytoplasm, Humans, Membrane Potentials, Mitochondria, Mitochondrial Membranes, Organophosphorus Compounds
Abstract

Mitochondrial function and dysfunction contributes to a range of important aspects of biomedical research. Consequently there is considerable interest in developing approaches to modify and report on mitochondria in cells and in vivo. One approach has been to target bioactive molecules to mitochondria by conjugating them to lipophilic cations. Due to the large mitochondrial membrane potential, the cations are accumulated within mitochondria inside cells. This approach had been used to develop mitochondria-targeted antioxidants that selectively block mitochondrial oxidative damage and prevent some types of cell death and also to develop probes of mitochondrial function. Here we outline some of the background to the development of these compounds.

DOI10.1016/j.bbabio.2008.03.029
Alternate JournalBiochim. Biophys. Acta
Citation Key10.1016/j.bbabio.2008.03.029
PubMed ID18439417
Grant ListMC_U105663142 / / Medical Research Council / United Kingdom
/ / Wellcome Trust / United Kingdom