|Title||Mammalian mitochondrial nucleoids: organizing an independently minded genome.|
|Publication Type||Journal Article|
|Year of Publication||2007|
|Authors||Holt, IJ, He, J, Mao, C-C, Boyd-Kirkup, JD, Martinsson, P, Sembongi, H, Reyes, A, Spelbrink, JN|
|Date Published||2007 Sep|
|Keywords||Adenosine Triphosphatases, Animals, ATPases Associated with Diverse Cellular Activities, Cells, Cultured, DNA Replication, DNA, Mitochondrial, DNA-Binding Proteins, Humans, Membrane Proteins, Mitochondria, Mitochondrial Diseases, Mitochondrial Membranes, Mitochondrial Proteins, Nucleoproteins, Saccharomyces cerevisiae|
Mitochondrial DNA is arranged in nucleoprotein complexes, or nucleoids. Nucleoid proteins include not only factors involved in replication and transcription but also structural proteins required for mitochondrial DNA maintenance. Although several nucleoid proteins have been identified and characterized in yeast over the course of the past decade, little was known of mammalian mitochondrial nucleoids until recently. Two publications in the past year have expanded considerably the pool of putative mammalian mitochondrial nucleoid proteins; and analysis of one of the candidates, ATAD3p, suggests that mitochondrial nucleoid formation and division are orchestrated, not random, events.
|Grant List||MC_U105663140 / / Medical Research Council / United Kingdom|