Mammalian mitochondrial nucleoids: organizing an independently minded genome.

TitleMammalian mitochondrial nucleoids: organizing an independently minded genome.
Publication TypeJournal Article
Year of Publication2007
AuthorsHolt, IJ, He, J, Mao, C-C, Boyd-Kirkup, JD, Martinsson, P, Sembongi, H, Reyes, A, Spelbrink, JN
Date Published2007 Sep
KeywordsAdenosine Triphosphatases, Animals, ATPases Associated with Diverse Cellular Activities, Cells, Cultured, DNA Replication, DNA, Mitochondrial, DNA-Binding Proteins, Humans, Membrane Proteins, Mitochondria, Mitochondrial Diseases, Mitochondrial Membranes, Mitochondrial Proteins, Nucleoproteins, Saccharomyces cerevisiae

Mitochondrial DNA is arranged in nucleoprotein complexes, or nucleoids. Nucleoid proteins include not only factors involved in replication and transcription but also structural proteins required for mitochondrial DNA maintenance. Although several nucleoid proteins have been identified and characterized in yeast over the course of the past decade, little was known of mammalian mitochondrial nucleoids until recently. Two publications in the past year have expanded considerably the pool of putative mammalian mitochondrial nucleoid proteins; and analysis of one of the candidates, ATAD3p, suggests that mitochondrial nucleoid formation and division are orchestrated, not random, events.

Alternate JournalMitochondrion
Citation Key10.1016/j.mito.2007.06.004
PubMed ID17698423
Grant ListMC_U105663140 / / Medical Research Council / United Kingdom