Phytoestrogen exposure, polymorphisms in COMT, CYP19, ESR1, and SHBG genes, and their associations with prostate cancer risk.

TitlePhytoestrogen exposure, polymorphisms in COMT, CYP19, ESR1, and SHBG genes, and their associations with prostate cancer risk.
Publication TypeJournal Article
Year of Publication2006
AuthorsLow, Y-L, Taylor, JI, Grace, PB, Mulligan, AA, Welch, AA, Scollen, S, Dunning, AM, Luben, RN, Khaw, K-T, Day, NE, Wareham, NJ, Bingham, SA
JournalNutr Cancer
Volume56
Issue1
Pagination31-9
Date Published2006
ISSN0163-5581
KeywordsAged, Biomarkers, Diet, Genotype, Humans, Male, Middle Aged, Odds Ratio, Phytoestrogens, Polymorphism, Single Nucleotide, Prospective Studies, Prostatic Neoplasms, Risk Factors, United States
Abstract

Prospective phytoestrogen exposure was assessed using both biomarkers and estimates of intake in 89 British men recruited into the Norfolk arm of the European Prospective Investigation into Cancer and Nutrition study, men who subsequently developed prostate cancer. Results were compared with those from 178 healthy men matched by age and date of recruitment. Levels of seven phytoestrogens (daidzein, genistein, glycitein, O-desmethylangolensin, equol, enterodiol, and enterolactone) were measured in spot urine and serum samples. Five single-nucleotide polymorphisms in COMT, CYP19, ESR1, and SHBG genes were genotyped. Urinary levels of all phytoestrogens correlated strongly with serum levels. Correlation coefficients ranged from 0.63 (glycitein) to 0.88 (daidzein) (P < 0.001). Urinary and serum levels correlated significantly with isoflavone intake assessed from food diaries (R = 0.15-0.20; P < 0.05) but not with that from a food-frequency questionnaire. Odds ratios for phytoestrogen exposure, as assessed using the four methods, were not significantly associated with prostate cancer risk (P = 0.15-0.94). Men with the CC genotype for the ESRI PvuII polymorphism had significantly higher risk for prostate cancer compared with men with the TT genotype [adjusted odds ratio = 4.65 (1.60-13.49); P = 0.005]. Our results utilizing a combined prospective exposure provide no evidence that phytoestrogens alter prostate cancer risk in British men, whereas the C allele for the PvuII polymorphism may be associated with increased risk.

DOI10.1207/s15327914nc5601_5
Alternate JournalNutr Cancer
Citation Key10.1207/s15327914nc5601_5
PubMed ID17176215
Grant ListG0401527 / / Medical Research Council / United Kingdom
MC_U106179471 / / Medical Research Council / United Kingdom