|Title||Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3.|
|Publication Type||Journal Article|
|Year of Publication||2005|
|Authors||Brand, MD, Esteves, TC|
|Date Published||2005 Aug|
|Keywords||Aging, Animals, Carrier Proteins, Fatty Acids, Insulin, Insulin Secretion, Ion Channels, Membrane Transport Proteins, Mitochondria, Mitochondrial Proteins, Obesity, Oxidation-Reduction, Oxidative Stress, Protein Isoforms, Reactive Oxygen Species, Thermogenesis, Uncoupling Protein 2, Uncoupling Protein 3|
Evidence for the physiological functions of UCP2 and UCP3 is critically reviewed. They do not mediate adaptive thermogenesis, but they may be significantly thermogenic under specific pharmacological conditions. There is strong evidence that the mild regulated uncoupling they cause attenuates mitochondrial ROS production, protects against cellular damage, and diminishes insulin secretion. Evidence that they export fatty acids physiologically is weak. UCP2 and UCP3 are important potential targets for treatment of aging, degenerative diseases, diabetes, and perhaps obesity.
|Alternate Journal||Cell Metab.|