|Title||Haem, not protein or inorganic iron, is responsible for endogenous intestinal N-nitrosation arising from red meat.|
|Publication Type||Journal Article|
|Year of Publication||2003|
|Authors||Cross, AJane, Pollock, JRA, Bingham, SAnne|
|Date Published||2003 May 15|
|Keywords||Adult, Aged, Animals, Cattle, Cross-Over Studies, Dietary Supplements, Feces, Heme, Humans, Intestine, Large, Iron, Dietary, Male, Meat, Middle Aged, Nitrites, Nitroso Compounds|
Many N-nitroso compounds (NOC) are carcinogens. In this controlled study of 21 healthy male volunteers, levels of NOC on a high (420 grams) red meat diet were significantly greater (P = 0.001) than on a low (60 grams) meat diet but not significantly greater when an equivalent amount of vegetable protein was fed. An 8-mg supplement of haem iron also increased fecal NOC (P = 0.006) compared with the low meat diet, but 35-mg ferrous iron had no effect. Endogenous N-nitrosation, arising from ingestion of haem but not inorganic iron or protein, may account for the increased risk associated with red meat consumption in colorectal cancer.
|Alternate Journal||Cancer Res.|