Mitochondrial proton leak and the uncoupling protein 1 homologues.

TitleMitochondrial proton leak and the uncoupling protein 1 homologues.
Publication TypeJournal Article
Year of Publication2001
AuthorsStuart, JA, Cadenas, S, Jekabsons, MB, Roussel, D, Brand, MD
JournalBiochim Biophys Acta
Volume1504
Issue1
Pagination144-58
Date Published2001 Mar 01
ISSN0006-3002
KeywordsAmino Acid Sequence, Animals, Animals, Genetically Modified, Basal Metabolism, Carrier Proteins, Diffusion, Humans, Intracellular Membranes, Ion Channels, Membrane Proteins, Membrane Transport Proteins, Mitochondria, Mitochondrial Proteins, Models, Animal, Molecular Sequence Data, Proteins, Protons, RNA, Messenger, Sequence Alignment, Sequence Homology, Uncoupling Protein 1, Uncoupling Protein 2, Uncoupling Protein 3
Abstract

Mitochondrial proton leak is the largest single contributor to the standard metabolic rate (SMR) of a rat, accounting for about 20% of SMR. Yet the mechanisms by which proton leak occurs are incompletely understood. The available evidence suggests that both phospholipids and proteins in the mitochondrial inner membrane are important determinants of proton conductance. The uncoupling protein 1 homologues (e.g. UCP2, UCP3) may play a role in mediating proton leak, but it is unlikely they account for all of the observed proton conductance. Experimental data regarding the functions of these proteins include important ambiguities and contradictions which must be addressed before their function can be confirmed. The physiological role of the proton leak, and of the uncoupling protein 1 homologues, remains similarly unclear.

DOI10.1016/s0005-2728(00)00243-7
Alternate JournalBiochim. Biophys. Acta
Citation Key10.1016/s0005-2728(00)00243-7
PubMed ID11239491