Toward a control theory analysis of aging.

TitleToward a control theory analysis of aging.
Publication TypeJournal Article
Year of Publication2008
AuthorsMurphy, MP, Partridge, L
JournalAnnu Rev Biochem
Volume77
Pagination777-98
Date Published2008
ISSN0066-4154
KeywordsAging, Animals, Cell Count, Cell Survival, Cellular Senescence, Humans, Longevity, Metabolism, Models, Biological, Phenotype, Signal Transduction
Abstract

Aging is due to the accumulation of damage over time that affects the function and survival of the organism; however, it has proven difficult to infer the relative importance of the many processes that contribute to aging. To address this, here we outline an approach that may prove useful in analyzing aging. In this approach, the function of the organism is described as a set of interacting physiological systems. Degradation of their outputs leads to functional decline and death as a result of aging. In turn, degradation of the system outputs is attributable to changes at the next hierarchical level down, the cell, through changes in cell number or function, which are in turn a consequence of the metabolic history of the cell. Within this framework, we then adapt the methods of metabolic control analysis (MCA) to determine which modifications are important for aging. This combination of a hierarchical framework and the methodologies of MCA may prove useful both for thinking about aging and for analyzing it experimentally.

DOI10.1146/annurev.biochem.77.070606.101605
Alternate JournalAnnu. Rev. Biochem.
Citation Key10.1146/annurev.biochem.77.070606.101605
PubMed ID18318658
PubMed Central IDPMC4335186
Grant List081394 / / Wellcome Trust / United Kingdom
BB/D020786/1 / / Biotechnology and Biological Sciences Research Council / United Kingdom
MC_U105663142 / / Medical Research Council / United Kingdom