Research on mitochondria and aging, 2006-2007.

TitleResearch on mitochondria and aging, 2006-2007.
Publication TypeJournal Article
Year of Publication2007
AuthorsLambert, AJ, Brand, MD
JournalAging Cell
Volume6
Issue4
Pagination417-20
Date Published2007 Aug
ISSN1474-9718
KeywordsAging, Animals, DNA Damage, DNA, Mitochondrial, Electron Transport Complex I, Energy Metabolism, Humans, Longevity, Mice, Mitochondria, Oxidation-Reduction, Oxidative Stress, Reactive Oxygen Species
Abstract

This review focuses on some of the 'hot topics' that fall under the general heading 'mitochondria and aging'. For each selected topic, we highlight recent publications that have either addressed specific problems within the field or presented novel findings of interest regarding the links between mitochondria and aging. These include studies on the structure of complex I and the mechanisms of superoxide production by this complex; work showing a novel site of hydrogen peroxide production within mitochondria that is modulated by caloric restriction; explorations of the relationship between the rate of evolution of mitochondrial DNA and lifespan; a demonstration that mitochondrial DNA mutations do not limit lifespan in mice; and investigations of the effects of mitochondrial fission on aging. We also list other relevant articles of interest and suggest some key challenges for the field in the near future.

DOI10.1111/j.1474-9726.2007.00316.x
Alternate JournalAging Cell
Citation Key10.1111/j.1474-9726.2007.00316.x
PubMed ID17635416
Grant ListMC_U105663137 / / Medical Research Council / United Kingdom