Mitochondrial targeting of quinones: therapeutic implications.

TitleMitochondrial targeting of quinones: therapeutic implications.
Publication TypeJournal Article
Year of Publication2007
AuthorsCochemé, HM, Kelso, GF, James, AM, Ross, MF, Trnka, J, Mahendiran, T, Asin-Cayuela, J, Blaikie, FH, Manas, A-RB, Porteous, CM, Adlam, VJ, Smith, RAJ, Murphy, MP
JournalMitochondrion
Volume7 Suppl
PaginationS94-102
Date Published2007 Jun
ISSN1567-7249
KeywordsAdministration, Oral, Animals, Cations, Cell Membrane, Humans, Membrane Potential, Mitochondrial, Membrane Potentials, Mitochondria, Mitochondrial Diseases, Models, Biological, Models, Chemical, Organophosphorus Compounds, Oxygen, Quinones, Ubiquinone
Abstract

Mitochondrial oxidative damage contributes to a range of degenerative diseases. Ubiquinones have been shown to protect mitochondria from oxidative damage, but only a small proportion of externally administered ubiquinone is taken up by mitochondria. Conjugation of the lipophilic triphenylphosphonium cation to a ubiquinone moiety has produced a compound, MitoQ, which accumulates selectively into mitochondria. MitoQ passes easily through all biological membranes and, because of its positive charge, is accumulated several hundred-fold within mitochondria driven by the mitochondrial membrane potential. MitoQ protects mitochondria against oxidative damage in vitro and following oral delivery, and may therefore form the basis for mitochondria-protective therapies.

DOI10.1016/j.mito.2007.02.007
Alternate JournalMitochondrion
Citation Key10.1016/j.mito.2007.02.007
PubMed ID17449335
Grant ListMC_U105663142 / / Medical Research Council / United Kingdom