The mimivirus genome encodes a mitochondrial carrier that transports dATP and dTTP.

TitleThe mimivirus genome encodes a mitochondrial carrier that transports dATP and dTTP.
Publication TypeJournal Article
Year of Publication2007
AuthorsMonné, M, Robinson, AJ, Boes, C, Harbour, ME, Fearnley, IM, Kunji, ERS
JournalJ Virol
Volume81
Issue7
Pagination3181-6
Date Published2007 Apr
ISSN0022-538X
KeywordsAmino Acid Sequence, Animals, Biological Transport, Cattle, Deoxyadenine Nucleotides, DNA Viruses, Genome, Viral, Humans, Lactococcus lactis, Mitochondria, Molecular Sequence Data, Sequence Alignment, Thymine Nucleotides
Abstract

Members of the mitochondrial carrier family have been reported in eukaryotes only, where they transport metabolites and cofactors across the mitochondrial inner membrane to link the metabolic pathways of the cytosol and the matrix. The genome of the giant virus Mimiviridae mimivirus encodes a member of the mitochondrial carrier family of transport proteins. This viral protein has been expressed in Lactococcus lactis and is shown to transport dATP and dTTP. As the 1.2-Mb double-stranded DNA mimivirus genome is rich in A and T residues, we speculate that the virus is using this protein to target the host mitochondria as a source of deoxynucleotides for its replication.

DOI10.1128/JVI.02386-06
Alternate JournalJ. Virol.
Citation Key10.1128/JVI.02386-06
PubMed ID17229695
PubMed Central IDPMC1866048
Grant ListMC_U105663139 / / Medical Research Council / United Kingdom
MC_U105663148 / / Medical Research Council / United Kingdom
MC_U105674181 / / Medical Research Council / United Kingdom