Lipophilic triphenylphosphonium cations as tools in mitochondrial bioenergetics and free radical biology.

TitleLipophilic triphenylphosphonium cations as tools in mitochondrial bioenergetics and free radical biology.
Publication TypeJournal Article
Year of Publication2005
AuthorsRoss, MF, Kelso, GF, Blaikie, FH, James, AM, Cochemé, HM, Filipovska, A, Da Ros, T, Hurd, TR, Smith, RAJ, Murphy, MP
JournalBiochemistry (Mosc)
Volume70
Issue2
Pagination222-30
Date Published2005 Feb
ISSN0006-2979
KeywordsCations, Energy Metabolism, Free Radicals, Humans, Intracellular Membranes, Mitochondria, Models, Biological, Molecular Structure, Organophosphorus Compounds
Abstract

Lipophilic phosphonium cations were first used to investigate mitochondrial biology by Vladimir Skulachev and colleagues in the late 1960s. Since then, these molecules have become important tools for exploring mitochondrial bioenergetics and free radical biology. Here we review why these molecules are useful in mitochondrial research and outline some of the ways in which they are now being utilized.

DOI10.1007/s10541-005-0104-5
Alternate JournalBiochemistry Mosc.
Citation Key10.1007/s10541-005-0104-5
PubMed ID15807662