The role and structure of mitochondrial carriers.

TitleThe role and structure of mitochondrial carriers.
Publication TypeJournal Article
Year of Publication2004
AuthorsKunji, ERS
JournalFEBS Lett
Volume564
Issue3
Pagination239-44
Date Published2004 Apr 30
ISSN0014-5793
KeywordsAmino Acid Sequence, Animals, Fungal Proteins, Humans, Mitochondria, Mitochondrial ADP, ATP Translocases, Models, Molecular, Molecular Sequence Data, Protein Structure, Secondary, Protein Structure, Tertiary
Abstract

Members of the mitochondrial carrier family transport compounds over the inner mitochondrial membrane to link the biochemical pathways in the cytosol with those in the mitochondrial matrix. X-ray crystallography has recently provided us with the first atomic model of the bovine ADP/ATP carrier, which is a member of this family. The structure explains the typical three-fold sequence repeats and signature motif of mitochondrial carriers. However, the carrier was crystallised as a monomer in detergent, which is inconsistent with the consensus that mitochondrial carriers exist as homo-dimers. The projection structure of the yeast ADP/ATP carrier by electron crystallography shows that carriers could form homo-dimers in the membrane.

DOI10.1016/S0014-5793(04)00242-X
Alternate JournalFEBS Lett.
Citation Key10.1016/S0014-5793(04)00242-X
PubMed ID15111103