|Title||The role and structure of mitochondrial carriers.|
|Publication Type||Journal Article|
|Year of Publication||2004|
|Date Published||2004 Apr 30|
|Keywords||Amino Acid Sequence, Animals, Fungal Proteins, Humans, Mitochondria, Mitochondrial ADP, ATP Translocases, Models, Molecular, Molecular Sequence Data, Protein Structure, Secondary, Protein Structure, Tertiary|
Members of the mitochondrial carrier family transport compounds over the inner mitochondrial membrane to link the biochemical pathways in the cytosol with those in the mitochondrial matrix. X-ray crystallography has recently provided us with the first atomic model of the bovine ADP/ATP carrier, which is a member of this family. The structure explains the typical three-fold sequence repeats and signature motif of mitochondrial carriers. However, the carrier was crystallised as a monomer in detergent, which is inconsistent with the consensus that mitochondrial carriers exist as homo-dimers. The projection structure of the yeast ADP/ATP carrier by electron crystallography shows that carriers could form homo-dimers in the membrane.
|Alternate Journal||FEBS Lett.|