Diet and colorectal cancer prevention.

TitleDiet and colorectal cancer prevention.
Publication TypeJournal Article
Year of Publication2000
AuthorsBingham, SA
JournalBiochem Soc Trans
Volume28
Issue2
Pagination12-6
Date Published2000 Feb
ISSN0300-5127
KeywordsColon, Colorectal Neoplasms, Diet, Dietary Fiber, Fermentation, Humans, Meat, Nitrogen, Starch
Abstract

The majority of cancers are sporadic and epidemiological estimates suggest that up to 80% of colorectal cancer is attributable to diet. Epidemiologically, cross-sectional comparisons, case-control studies and trends in food intake show high rates of colorectal cancer in populations consuming diets high in meat and fat, and low in starch, NSP (non-starch polysaccharides, fibre) and vegetables. In general, prospective studies tend to support these findings although estimates of relative risk are not high. Existing prospective studies have however used crude indices of diet subject to substantial measurement error, and interactions with genetic polymorphisms in, for example, phase-I and -II enzymes have been studied only rarely. The association between meat consumption and colorectal cancer is usually attributed to the formation of heterocyclic amines in meat when it is cooked. In addition, in humans high-meat diets increase the level of nitrosatable material entering the colon so that faecal N-nitroso compounds (NOCs) increase in a dose-responsive manner following endogenous synthesis in the colon. Some of the mutations and guanine adducts accumulated during colorectal cancer progression are characteristic of alkylative damage, which would be compatible with NOC exposure. To date, NSP, resistant starch and vegetables have not reduced faecal NOC levels.

DOI10.1042/bst0280012
Alternate JournalBiochem. Soc. Trans.
Citation Key10.1042/bst0280012
PubMed ID10816091