Mitochondrial pyruvate import and its effects on homeostasis.

TitleMitochondrial pyruvate import and its effects on homeostasis.
Publication TypeJournal Article
Year of Publication2015
AuthorsVanderperre, B, Bender, T, Kunji, ERS, Martinou, J-C
JournalCurr Opin Cell Biol
Date Published2015 Apr
KeywordsAnimals, Glucose, Homeostasis, Humans, Membrane Transport Proteins, Mitochondria, Mitochondrial Membranes, Mutation, Neoplasms, Pyruvic Acid

Pyruvate metabolism plays a pivotal role in cell homeostasis and energy production. Pyruvate, the end product of glycolysis, is either catabolized in the cytosol, or enters into mitochondria to promote oxidative phosphorylation. The import of pyruvate into mitochondria requires a specific carrier in the inner mitochondrial membrane, the mitochondrial pyruvate carrier (MPC), whose identity was only recently discovered. Here we report our current knowledge of the structure and function of the MPC and we describe how dysfunction of the MPC could participate in various pathologies, including type 2 diabetes and cancer.

Alternate JournalCurr. Opin. Cell Biol.
Citation Key10.1016/
PubMed ID25463844
Grant ListMC_U105663139 / / Medical Research Council / United Kingdom