Mitochondrial pyruvate import and its effects on homeostasis.

TitleMitochondrial pyruvate import and its effects on homeostasis.
Publication TypeJournal Article
Year of Publication2015
AuthorsVanderperre, B, Bender, T, Kunji, ERS, Martinou, J-C
JournalCurr Opin Cell Biol
Volume33
Pagination35-41
Date Published2015 Apr
ISSN1879-0410
KeywordsAnimals, Glucose, Homeostasis, Humans, Membrane Transport Proteins, Mitochondria, Mitochondrial Membranes, Mutation, Neoplasms, Pyruvic Acid
Abstract

Pyruvate metabolism plays a pivotal role in cell homeostasis and energy production. Pyruvate, the end product of glycolysis, is either catabolized in the cytosol, or enters into mitochondria to promote oxidative phosphorylation. The import of pyruvate into mitochondria requires a specific carrier in the inner mitochondrial membrane, the mitochondrial pyruvate carrier (MPC), whose identity was only recently discovered. Here we report our current knowledge of the structure and function of the MPC and we describe how dysfunction of the MPC could participate in various pathologies, including type 2 diabetes and cancer.

DOI10.1016/j.ceb.2014.10.008
Alternate JournalCurr. Opin. Cell Biol.
Citation Key10.1016/j.ceb.2014.10.008
PubMed ID25463844
Grant List / / Medical Research Council / United Kingdom