Antioxidants as therapies: can we improve on nature?

TitleAntioxidants as therapies: can we improve on nature?
Publication TypeJournal Article
Year of Publication2014
AuthorsMurphy, MP
JournalFree Radic Biol Med
Volume66
Pagination20-3
Date Published2014 Jan
ISSN1873-4596
KeywordsAnimals, Antioxidants, Clinical Trials as Topic, Drug Design, Humans, Oxidation-Reduction, Oxidative Stress, Reactive Oxygen Species
Abstract

Although oxidative damage contributes to many pathologies the use of naturally occurring, small-molecule antioxidants as therapies for these disorders has not been successful. Here I discuss some of the reasons this may be so. Paramount among these are the difficulties in delivering enough of the antioxidant to the intracellular location required to decrease pathological oxidative damage and the challenge of assessing whether the intervention has actually decreased oxidative damage in the patient to a therapeutically useful extent. To develop effective antioxidant therapies the best strategy may be to create new chemical entities designed to detoxify a defined reactive oxygen species-dependent process that underlies a particular pathology, in the same way a conventional drug is designed to modulate a biochemical process, rather than applying antioxidants in an unfocused manner. In developing new antioxidants it will be useful to utilize endogenous processes to activate and recycle the molecules in parallel with the targeting of compounds to cells and organelles in ways that are not limited by the constraints that impair the distribution of endogenous antioxidants. In short, I suggest that the future development of antioxidant therapies should be viewed as an arm of drug development, utilizing focused approaches similar to those of medicinal chemistry and pharmacology, rather than as a branch of nutrition.

DOI10.1016/j.freeradbiomed.2013.04.010
Alternate JournalFree Radic. Biol. Med.
Citation Key10.1016/j.freeradbiomed.2013.04.010
PubMed ID23603661
Grant ListMC_U105663142 / / Medical Research Council / United Kingdom