Mitochondrial dysfunction indirectly elevates ROS production by the endoplasmic reticulum.

TitleMitochondrial dysfunction indirectly elevates ROS production by the endoplasmic reticulum.
Publication TypeJournal Article
Year of Publication2013
AuthorsMurphy, MP
JournalCell Metab
Volume18
Issue2
Pagination145-6
Date Published2013 Aug 06
ISSN1932-7420
KeywordsCytochrome-c Oxidase Deficiency, Electron Transport Complex IV, ras Proteins, Reactive Oxygen Species, Saccharomyces cerevisiae
Abstract

Mitochondrial dysfunction is often associated with increased reactive oxygen species (ROS) production by the organelle itself. Leadsham et al. (2013) now show that the link between mitochondrial damage and ROS is more complicated, at least in yeast, where signals from damaged mitochondria increase ROS production from the endoplasmic reticulum surface.

DOI10.1016/j.cmet.2013.07.006
Alternate JournalCell Metab.
Citation Key10.1016/j.cmet.2013.07.006
PubMed ID23931748
Grant ListMC_U105663142 / / Medical Research Council / United Kingdom