Minimizing the damage: repair pathways keep mitochondrial DNA intact.

TitleMinimizing the damage: repair pathways keep mitochondrial DNA intact.
Publication TypeJournal Article
Year of Publication2012
AuthorsKazak, L, Reyes, A, Holt, IJ
JournalNat Rev Mol Cell Biol
Volume13
Issue10
Pagination659-71
Date Published2012 Oct
ISSN1471-0080
KeywordsAnimals, Cell Nucleus, DNA Breaks, DNA Ligases, DNA Repair, DNA, Mitochondrial, DNA-(Apurinic or Apyrimidinic Site) Lyase, Humans, Mitochondria
Abstract

Mitochondrial DNA (mtDNA) faces the universal challenges of genome maintenance: the accurate replication, transmission and preservation of its integrity throughout the life of the organism. Although mtDNA was originally thought to lack DNA repair activity, four decades of research on mitochondria have revealed multiple mtDNA repair pathways, including base excision repair, single-strand break repair, mismatch repair and possibly homologous recombination. These mtDNA repair pathways are mediated by enzymes that are similar in activity to those operating in the nucleus, and in all cases identified so far in mammals, they are encoded by nuclear genes.

DOI10.1038/nrm3439
Alternate JournalNat. Rev. Mol. Cell Biol.
Citation Key10.1038/nrm3439
PubMed ID22992591
Grant ListMC_U105663140 / / Medical Research Council / United Kingdom
/ / Medical Research Council / United Kingdom