Mitochondrial carrier homolog 2 (MTCH2): the recruitment and evolution of a mitochondrial carrier protein to a critical player in apoptosis.

TitleMitochondrial carrier homolog 2 (MTCH2): the recruitment and evolution of a mitochondrial carrier protein to a critical player in apoptosis.
Publication TypeJournal Article
Year of Publication2012
AuthorsRobinson, AJ, Kunji, ERS, Gross, A
JournalExp Cell Res
Volume318
Issue11
Pagination1316-23
Date Published2012 Jul 01
ISSN1090-2422
KeywordsAnimals, Apoptosis, Choanoflagellata, Evolution, Molecular, Humans, Mitochondrial Membrane Transport Proteins, Mitochondrial Proteins, Protein Transport
Abstract

Recent studies report mitochondrial carrier homolog 2 (MTCH2) as a novel and uncharacterized protein that acts as a receptor-like protein for the truncated BH3-interacting domain death agonist (tBID) protein in the outer membrane of mitochondria. These studies, using mouse embryonic stem cells and fibroblasts as well as mice with a conditional knockout of MTCH2 in the liver, showed that deletion of MTCH2 hindered recruitment of tBID to the mitochondria with subsequent reductions in the activation of pro-apoptotic proteins, mitochondrial outer membrane permeabilization and apoptosis. Sequence analysis shows that MTCH2 is present in all examined multicellular Metazoa as well as unicellular Choanoflagellata, and is a highly derived member of the mitochondrial carrier family. Mitochondrial carriers are monomeric transport proteins that are usually found in the inner mitochondrial membrane, where they exchange small substrates between the mitochondrial matrix and intermembrane space. There are extensive differences between the protein sequences of MTCH2 and other mitochondrial carriers that may explain the ability of MTCH2 to associate with tBID and thus its role in apoptosis. We review the experimental evidence for the role of MTCH2 in apoptosis and suggest that the original transport function of the ancestral MTCH2 mitochondrial carrier has been co-opted by the apoptotic machinery to provide a receptor and signaling mechanism.

DOI10.1016/j.yexcr.2012.01.026
Alternate JournalExp. Cell Res.
Citation Key10.1016/j.yexcr.2012.01.026
PubMed ID22326460
Grant ListMC_U105663139 / / Medical Research Council / United Kingdom
MC_U105674181 / / Medical Research Council / United Kingdom