The post-transcriptional life of mammalian mitochondrial RNA.

TitleThe post-transcriptional life of mammalian mitochondrial RNA.
Publication TypeJournal Article
Year of Publication2012
AuthorsRorbach, J, Minczuk, MA
JournalBiochem J
Volume444
Issue3
Pagination357-73
Date Published2012 Jun 15
ISSN1470-8728
KeywordsAnimals, Humans, Mammals, RNA, RNA Processing, Post-Transcriptional, Signal Transduction
Abstract

Mammalian mitochondria contain their own genome that encodes mRNAs for thirteen essential subunits of the complexes performing oxidative phosphorylation as well as the RNA components (two rRNAs and 22 tRNAs) needed for their translation in mitochondria. All RNA species are produced from single polycistronic precursor RNAs, yet the relative concentrations of various RNAs differ significantly. This underscores the essential role of post-transcriptional mechanisms that control the maturation, stability and translation of mitochondrial RNAs. The present review provides a detailed summary on the role of RNA maturation in the regulation of mitochondrial gene expression, focusing mainly on messenger RNA polyadenylation and stability control. Furthermore, the role of mitochondrial ribosomal RNA stability, processing and modifications in the biogenesis of the mitochondrial ribosome is discussed.

DOI10.1042/BJ20112208
Alternate JournalBiochem. J.
Citation Key10.1042/BJ20112208
PubMed ID22642575
Grant ListMC_U105697135 / / Medical Research Council / United Kingdom
/ / Medical Research Council / United Kingdom