The Unit has a comprehensive public engagement programme. This includes:
- visits to local schools and other organisations
- participation in the Cambridge Science Festival, where we exhibit every year
- our annual Open Day
- involvement in other events for public understanding of science.
- engagement with artists and designers on the artistic interpretation of our science.
For further information about the activities of the Unit, please contact our Communications Manager, Penny Peck (communicationsmrc-mbu [dot] cam [dot] ac [dot] uk).
On 25 June 2014 the MRC Mitochondrial Biology Unit (MBU) opened its doors again to the public.
Visitors included local residents and students from local sixth form colleges. MBU scientists gave a series of talks and demonstrations on mitochondria and how mitochondrial dysfunction leads to illness and ageing.
Visitors also attended a “meet the scientists” session, where members further explained their work through the use of posters, movies and video games.
On 23 March 2014 at the Cambridge Science Festival, scientists from the MRC Mitochondrial Biology Unit (MBU) used posters, movies and computer games, created by Henry Harling, to demonstrate how mitochondrial dysfunction leads to illness and ageing.
Visitors were given an explanation of heteroplasmy - when an individual has mutant as well as normal mitochondrial DNA - which was demonstrated by the Heteroplasmy video game.
To celebrate the Centenary of the Medical Research Council, the Mitochondrial Biology Unit opened its doors to the public on 20 June 2013 for demonstrations and presentations based on the theme ‘How do we get energy out of food?’
The festival this year saw the premiere of three new animations. The first animation shows all of the major organelles of the human cell, including a dynamic network of mitochondria that are involved in fusion and fission events. The basic structure of a mitochondrion with the inner and outer membrane and cristae is also explained. The second one illustrates some of the major events of energy conversion at the mitochondrial inner membrane, featuring isocitrate dehydrogenase, Complex I, ATP synthase, mitochondrial transport proteins, the voltage gated anion channel, and hexokinase.
To highlight the central role that mitochondria play in cellular energy metabolism, we produced an animation showing the breakdown of a simple sugar molecule; from its uptake in the intestine to the series of energy conversion steps that lead to the synthesis of ATP in the mitochondrial matrix. After the sugar molecule enters the blood stream in the intestine, it is taken up by the human cell and undergoes a series of breakdown reactions in the cytoplasm of the cell to form pyruvate, which is subsequently transported into the mitochondrion (see figure below).
Using the three-dimensional structures of the Fo and F1 domains of ATP synthase determined by Professor Sir John Walker and collaborators we constructed an accurate three-dimensional representation of the protein complex in LEGO. The model, consisting of approximately 15,000 LEGO bricks and built to a scale of 50,000,000:1, clearly shows the different functional domains of the complex. Participants were invited to build miniature LEGO models of the ATP synthase and complex I (the structure of which was solved in the laboratory of Dr. Sazanov).