science festival

Cambridge Science Festival 2013

The festival this year saw the premiere of three new animations. The first animation shows all of the major organelles of the human cell, including a dynamic network of mitochondria that are involved in fusion and fission events. The basic structure of a mitochondrion with the inner and outer membrane and cristae is also explained. The second one illustrates some of the major events of energy conversion at the mitochondrial inner membrane, featuring isocitrate dehydrogenase, Complex I, ATP synthase, mitochondrial transport proteins, the voltage gated anion channel, and hexokinase.

Cambridge Science Festival 2012

To highlight the central role that mitochondria play in cellular energy metabolism, we produced an animation showing the breakdown of a simple sugar molecule; from its uptake in the intestine to the series of energy conversion steps that lead to the synthesis of ATP in the mitochondrial matrix. After the sugar molecule enters the blood stream in the intestine, it is taken up by the human cell and undergoes a series of breakdown reactions in the cytoplasm of the cell to form pyruvate, which is subsequently transported into the mitochondrion (see figure below).

Cambridge Science Festival 2011

Using the three-dimensional structures of the Fo and F1 domains of ATP synthase determined by Professor Sir John Walker and collaborators we constructed an accurate three-dimensional representation of the protein complex in LEGO. The model, consisting of approximately 15,000 LEGO bricks and built to a scale of 50,000,000:1, clearly shows the different functional domains of the complex. Participants were invited to build miniature LEGO models of the ATP synthase and complex I (the structure of which was solved in the laboratory of Dr. Sazanov).

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