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The Cambridge Green Challenge – Bronze Award for the MRC MBU

We are extremely proud to share the news that the MRC MBU’s Green Team has been awarded the Bronze award for the 2020-2021 academic year by the Sustainability Team at the University of Cambridge.

The auditor really enjoyed meeting members of the team, saying that “It was a pleasure to audit this team, they’ve done fantastic work implementing new sustainability measures across their unit and there’s excellent energy and enthusiasm from the team.”

MBU scientists secure continued funding for research on Pearson Syndrome

Michal Minczuk, leader of the MRC MBU's Mitochondrial Genetics research group, has been awarded a further grant from The Champ Foundation to continue his research into Pearson Syndrome - a multi-system disease caused by a deletion in mitochondrial DNA.

Funding was awarded in 2017 for a two-year project, which led to the development of a new DNA-editing tool aimed at generating mouse models for diseases caused by mitochondrial DNA deletions using various engineered nucleases.

An atlas of mitochondrial DNA genotype-phenotype associations in the UK Biobank

Mother and Child - Bruno Nascimento

Published in Nature Genetics, a collaboration between Public Health and Primary Care, Clinical Neurosciences and the MRC Mitochondrial Biology Unit has shown that genetic variants of maternally-inherited mitochondrial DNA (mtDNA) modify our risk of developing common diseases including type 2 diabetes and multiple sclerosis, and also affect our liver and kidney function, and many different blood cell measurements.

Interface mobility between monomers in dimeric bovine ATP synthase participates in the ultrastructure of inner mitochondrial membranes

Dimeric ATP synthase accommodates itself to the membrane curvature in mitochondrial cristae along th

In a research article published in Proceedings of the National Academy of Sciences, USA, Tobias Spikes, Martin Montgomery and John Walker have shown how the mobility in the interfaces between monomers in dimeric bovine ATP synthase participates in forming the characteristic and ever-changing ultrastructure of inner mitochondrial membranes. This article has been selected by the PNAS as a research highlight.

Structural insights into the role of mitochondrial complex I in heart attack

A collaborative research project led by Professor Judy Hirst at the MBU, working with Mike Murphy (MBU) and Thomas Krieg (Medicine), provides important new insights into the cell damage that occurs during heart attacks. This work, published in Nature Communications with MBU PhD student Zhan Yin as first author, focuses on a version of mitochondrial complex I that contains a single amino acid mutation.

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