Projects

Atomic structures of mitochondrial transport proteins

Calcium regulation of mitochondrial carriers

Computational drug discovery

Defects of mitochondrial gene expression in human disease

Diseases caused by mitochondrial transport proteins

Electron microscopy of mitochondrial transport proteins

Evolution of the structure of ATP synthase

Exome sequencing for mitochondrial disease

Genetic modification of the mitochondrial genome

Identification of mitochondrial transport proteins

Mitochondrial carrier proteins

Mitochondrial Complex I

Mitochondrial Exomarkers

Mitochondrial Therapies

MitoCore metabolic model

MitoMiner localisation database

Modelling mitochondrial metabolism

Molecular anatomy of mitochondrial disease

Novel therapies: activation of biogenesis

Novel therapies: gene replacement

Protein methylation

Regulation of mitochondrial gene expression

Role of cardiolipin in mitochondrial carriers

Structural and functional analysis of the mitochondrial pyruvate carrier

Substrate binding and proton coupling

Subunit composition of ATP synthase

The biogenesis and assembly of the human ATP synthase

The mitochondrial proteome (IMPI)

The structure and function of ATP synthases

Thiol Proteomics

Transport mechanism of mitochondrial carriers