The role of mitochondrial transcriptional processes in modulating human health and disease
Mitochondrial dysfunction is implicated in a wide range of human diseases, yet its causal role and the reasons for tissue-specific manifestations remain poorly understood. Here we show, using large-scale genetic and transcriptomic data, that nuclear regulation of mitochondrial gene expression contributes to complex trait biology. Our analyses reveal tissue-dependent mechanisms linking mitochondrial processes to disease risk and highlight opportunities for understanding and potentially targeting mitochondrial contributions to human health.
Date:
Wednesday, 24 September, 2025 - 15:00 to 16:00
Event location:
Level 7 Lecture Theatre, The Keith Peters Building, CB2 0XY