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MRC Mitochondrial Biology Unit


Research Resources

MBU researchers have developed several databases, tools and software packages useful to the community.

MitoPhen. In this database the clinical phenotypes of ~7k published individuals with close to a 100 pathogenic mtDNA mutations were curated and analysed for phenotypes.                                 
Mitominer. This database provides an overview of the evidence for a protein's designation as mitochondrial from over one hundred published experimental and computational datasets. Read more.
ComPrAn. This R package has been designed to help the analysis and visualization of proteomics data resulting from complexomics profiling experiments.
The Integrated Mitochondrial Protein Index - IMPI. This database collates human genes encoding proteins with strong evidence for mitochondrial localisation.
MitoCore is a computer model of human central metabolism developed in collaboration with the University of Bordeaux.


Facilities and Equipment

The MBU currently hosts the following in-house facilities, helping our researches, collaborators and neighbouring institutions accessing contemporary and emerging technologies:

  • Proteomics facility, equipped with two OrbiTrap instruments.
  • Light microscopy facility, equipped with two state-of-the-art confocal microscopes (Zeiss LSM 880 confocal scanning system and an Andor Dragonfly spinning disk setup) and a N-Structured Illumination Microscopy (SIM) super resolution microscope.
  • High performance computing cluster, with serval GPU and CPU nodes.
  • The Unit also provides centralised, technical support for animal model work, cell culture and fermentation

The integration of the MBU into the University of Cambridge allows our members to access University facilities. Important examples include:

  • CryoEM facility in the Department of Biochemistry
  • TEM facility in the Wellcome-MRC Cambridge Stem Cell Institute
  • Genomics core facility at CRUK Cambridge Institute
  • Cambridge Advanced Imaging Centre
  • Cambridge Centre for Proteomics
  • NIHR Cambridge BRC Cell Phenotyping Hub
  • Fly Facility in the Department of Genetics.

To enquire about access to MBU facilities contact the MBU Lab Management team

Research Resources and Facilities