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MRC Mitochondrial Biology Unit


Lindsey Van Haute











Dr. Lindsey Van Haute studied Biomedical Sciences at the University of Antwerp, Belgium, where she also obtained a MSc in Human Biology. After a short break working in the pharmaceutical industry, Lindsey completed her PhD at the University of Brussels, Belgium. Her work focussed on human embryonic stem cells, both differentiation and the study of the mitochondrial genome. The latter triggered her interest to research mitochondrial transcription and translation and the establishment of mitochondrial mutation models, which led her move to the MBU in 2013 after she was granted an EMBO post-doctoral fellowship.  She now holds a position Investigator Scientist in the group of Dr. Michal Minczuk. More recently, Lindsey has founded a data analysis company that focuses on custom made NGS analysis, both for mitochondrial research and other research areas.

Dr. Lindsey Van Haute established the MBU Postdoc Society in the MBU of which she remained chair. Lindsey is also the MBU Equality Champion and member of the Unit’s WIDE committee.

Research Interests

Dr. Lindsey Van Haute has a strong interest in the technical aspects of next generation sequencing (NGS). NGS is a constantly evolving technique, making it crucial to constantly develop new protocols both for the wet-lab aspect and for the analysis pipelines. Lindsey uses her expertise to advise group members how to design their NGS project and to analyse and develop new NGS data analysis scripts for her own research projects as well as for others. This includes a wide range of NGS data analysis topics, such as RNA-seq, epigenetic sequencing and gene editing off-target effects.

Figure legend: NGS analysis played a crucial role in the research of how mutations in the TEFM gene cause disease.

Selected Publications

Van Haute L, O'Connor E, Díaz-Maldonado H, Munro B, Polavarapu K, Hock DH, Arunachal G, Athanasiou-Fragkouli A, Bardhan M, Barth M, Bonneau D, Brunetti-Pierri N, Cappuccio G, Caruana NJ, Dominik N, Goel H, Helman G, Houlden H, Lenaers G, Mention K, Murphy D, Nandeesh B, Olimpio C, Powell CA, Preethish-Kumar V, Procaccio V, Rius R, Rebelo-Guiomar P, Simons C, Vengalil S, Zaki MS, Ziegler A, Thorburn DR, Stroud DA, Maroofian R, Christodoulou J, Gustafsson C, Nalini A, Lochmüller H, Minczuk M, Horvath R (2023)
TEFM variants impair mitochondrial transcription causing childhood-onset neurological disease.
Nature Communications 23;14(1):1009

Van Haute L, Hendrick AG, D'Souza AR, Powell CA, Rebelo-Guiomar P, Harbour ME, Ding S, Fearnley IM, Andrews B, Minczuk M (2019)
METTL15 introduces N4-methylcytidine into human mitochondrial 12S rRNA and is required for mitoribosome biogenesis.
Nucleic Acids Research 47(19):10267-10281

Van Haute L, Dietmann S, Kremer L, Hussain S, Pearce SF, Powell CA, Rorbach J, Lantaff R, Blanco S, Sauer S, Kotzaeridou U, Hoffmann GF, Memari Y, Kolb-Kokocinski A, Durbin R, Mayr JA, Frye M, Prokisch H, Minczuk M (2016)

Deficient methylation and formylation of mt-tRNA(Met) wobble cytosine in a patient carrying mutations in NSUN3.
Nature Communications 7:12039