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MRC Mitochondrial Biology Unit


Pedro Silva Pinheiro

Preferred first name: Pedro













Pedro Silva-Pinheiro is a Research Associate at the MRC Mitochondrial Biology Unit in Cambridge, UK. He received his BS in Genetics and Biotechnology and a MSc in Molecular Medicine from the University of Porto, Portugal. During his MSc, Silva-Pinheiro was awarded a Fulbright Scholarship allowing to carry his research at the University of Alabama in Birmingham, US, studying the effects of mitochondrial DNA mutations in lipid metabolism. Then, he joined the group of Massimo Zeviani in the MRC Mitochondrial Biology Unit, University of Cambridge supported by a Marie Skłodowska-Curie PhD studentship. During his PhD, Silva-Pinheiro focused on the pathogenesis and development of therapies for mitochondrial diseases using mouse models. Silva-Pinheiro has now joined the group of Michal Minczuk in the MRC Mitochondrial Biology Unit where he focus on mitochondrial DNA editing techniques.

Research Interests

Pedro Silva-Pinheiro current research interests lie on the development and application of new methods for manipulation of the mitochondrial DNA (TALE nucleases and base editors - DdCBEs), allowing for the generation of new models of mitochondrial disease and novel therapeutic platforms.

Selected Publications

Silva-Pinheiro P, Mutti CD, Van Haute L, Powell CA, Nash PA, Turner KT, Minczuk M (2022)  
A library of base editors for the precise ablation of all protein-coding genes in the mouse mitochondrial genome.
Nat Biomed Eng doi:10.1038/s41551-022-00968-1

Silva-Pinheiro P, Nash PA, Van Haute L, Mutti CD, Turner K, Minczuk M (2022)
In vivo mitochondrial base editing via adeno-associated viral delivery to mouse post-mitotic tissue.
Nat Commun 13, 750 (2022)