MRC Mitochondrial Biology Unit |

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The strategic mission of the MBU is to understand mitochondrial biology in health and disease, and to exploit this understanding to develop new therapies and improve human health.

Rapid mitochondrial repolarization upon reperfusion after cardiac ischemia

16 December 2025

The results of a collaborative research study jointlyled Mike Murphy’s laboratory have been published in Nature Cardiovascular Research . In the research article, scientists at the MBU and the Department of Medicine , University of Cambridge and the National Heart, Lung and Blood Institute (NHLBI), NIH, Bethesda, USA...

Hydrogen sulfide signalling: new analytical tools and therapeutic perspectives

9 December 2025

Hydrogen sulfide (H₂S) is increasingly recognised as an important signalling molecule in biological systems. It can reversibly modify low molecular weight (L MW SH) and protein (PrSH) thiols to form persulfides (RSS ⁻ ) and polysulfides (RS(S) ₙ S ⁻ ), contributing to antioxidant defence and the regulation of protein...

Kath Hammond awarded best short talk prize at Wellcome Connecting Science conference

14 November 2025

We are proud to share the news that Kath Hammond, a second year PhD student in Professor Mike Murphy's research group, was awarded a prize for the "best short talk" at the recent Wellcome Connecting Science: Mitochondrial medicine - Therapeutic development conference. Kath's presentation focused on the active/deactive...

Big Biology Day 2025

23 October 2025

On Saturday, 11 October 2025, thirteen members of the MBU participated in the Big Biology Day, held at Hills Road Sixth Form College. Using hands on, interactive activities, MBU members (senior and junior scientists) showcased the Unit's research on mitochondria, giving explanations and career advice. Our activities this...

Mouse models show potential for the clinical treatment of heteroplasmic mitochondrial disease

9 October 2025

New research carried out by members of Patrick Chinnery’s group has been published in Science . The article, “ Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations ” explains how mitochondrial mutations can overcome the intrinsic cellular quality control systems to cause disease and how to...

John Walker gives opening lecture at the 15th International Congress on In-born Errors of Metabolism (Kyoto)

23 September 2025

On 3 September 2025, John Walker gave the opening lecture at the 15th International Congress on In-born Errors of Metabolism held in Kyoto, Japan. The lecture, given before an audience of over 1200 delegates, was entitled “My Life in the Mitochondrion”.

Study in mice shows potential for new treatment to reduce brain damage from stroke

6 August 2025

Cambridge scientists have developed and tested a new drug in mice that has the potential to reduce damage to the brain following stroke – a problem that affects more than nine in 10 stroke patients. Results from a collaborative research study led by Professors Mike Murphy and Thomas Krieg , working with a mouse model...

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MRC Mitochondrial Biology Unit

mrc_mbu_cambridge_rgb.png

mrc_mbu_cambridge_rgb.png

The strategic mission of the MBU is to understand mitochondrial biology in health and disease, and to exploit this understanding to develop new therapies and improve human health.

Rapid mitochondrial repolarization upon reperfusion after cardiac ischemia

Hydrogen sulfide signalling: new analytical tools and therapeutic perspectives

Kath Hammond awarded best short talk prize at Wellcome Connecting Science conference

Big Biology Day 2025

Mouse models show potential for the clinical treatment of heteroplasmic mitochondrial disease

John Walker gives opening lecture at the 15th International Congress on In-born Errors of Metabolism (Kyoto)

Study in mice shows potential for new treatment to reduce brain damage from stroke

bluesky-web.png

Interested in doing a PhD at the MBU?

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