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MRC Mitochondrial Biology Unit

 

The strategic mission of the MBU is to understand mitochondrial biology in health and disease, and to exploit this understanding to develop new therapies and improve human health.

 


 

Read more at: Mito warriors: scientists discover how T cell assassins reload their weapons to kill and kill again - new footage shows T cells hunting down and destroying cancer cells

Mito warriors: scientists discover how T cell assassins reload their weapons to kill and kill again - new footage shows T cells hunting down and destroying cancer cells

18 October 2021

Professor Gillian Griffiths (CIMR) and her research group, in collaboration with Dr Julien Prudent (MBU), have discovered how T cells – an important component of our immune system – are able keep on killing as they hunt down and kill cancer cells, repeatedly reloading their toxic weapons. Cytotoxic T cells are specialist...


Read more at: World Mitochondrial Disease Week

World Mitochondrial Disease Week

20 September 2021

This week (19-25 September, 2021) is World Mitochondrial Disease Week . Every year, monuments around the world are lit up green to raise awareness for mitochondrial disease (mito). 2021's Light Up for Mito will take place in participating countries on Saturday, 25 September 2021. Contributions on twitter can be found by...


Read more at: Linking chemotherapy resistance to mitochondrial Ca2+-dependent cell death

Linking chemotherapy resistance to mitochondrial Ca2+-dependent cell death

13 September 2021

SMARCA4 and SMARCA2 are two mutually exclusive ATPase subunits of the SWI/SNF family, which are involved in chromatin remodeling to control gene expression. Dual loss of SMARCA4/2, by mutations and other mechanisms, has been shown to be responsible for a subset of lung (non-small cell) and ovarian (small cell carcinoma of...


Read more at: Cell reprogramming shapes the mitochondrial DNA
Fig.!. mtDNA heteroplasmic variants detected from whole-genome sequences

Cell reprogramming shapes the mitochondrial DNA

3 September 2021

Nature Communications has published the results of a research study led by Professor Patrick Chinnery , which show that the dynamic mtDNA landscape contributes to the heterogeneity of human iPSCs. Individual induced pluripotent stem cells (iPSCs) show considerable phenotypic heterogeneity, but the reasons for this are not...


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