MRC Mitochondrial Biology Unit |

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The strategic mission of the MBU is to understand mitochondrial biology in health and disease, and to exploit this understanding to develop new therapies and improve human health.

Atomic details revealed of a key protein involved in the burning of fat

31 May 2023

The results of a collaborative research study led by Professors Edmund Kunji and Vera Moiseenkova-Bell , involving scientists from the Universities of Cambridge, Pennsylvania, East Anglia and Brussels, have been published in Science Advances . Uncoupling protein 1 (UCP1) is the protein that allows specialised brown fat...

MBU Researchers at PInt of Science (Cambridge)

25 May 2023

Pint of Science is a worldwide science festival which brings researchers to your local pub/cafe/space to share their scientific discoveries with you - no prior knowledge required. The event recently took place in 37 towns and cities across the UK and Dr Stephen Burr (senior postdoctoral researcher in the Chinnery group)...

Potential new therapeutic target for inflammatory diseases

29 March 2023

The results of a collaborative research study recently published in Nature , with Dylan Ryan as co-corresponding author, identifies fumarate hydratase (FH) as a potential new therapeutic target for inflammatory diseases. Macrophages are a frontline inflammatory cell type that are implicated in a range of diseases including...

Cambridge Festival 2023

29 March 2023

On 18 March, the MBU joined other scientific organisations based on the Cambridge Biomedical Campus for our first CBC in-person Cambridge Festival event since lockdown. Alongside Penny Peck and Alex Whitworth , Alva Casey ( Murphy Group ), Dnyanesh Dubal ( van den Ameele Group ), Alannah King ( Kunji Group ), Nell Nie (...

New discovery unveils how fumarate drives mitochondria to release their DNA through vesicles formation to induce innate immunity

8 March 2023

Every cell in the body contains a small organelle, called mitochondrion, that houses thousands of biochemical reactions essential for life. These reactions provide energy for cells through the breakdown of sugar and fat, also generating the building blocks to make protein and DNA. Each cell has hundreds of individual...

MBU researchers help discover a new therapeutic strategy for a common form of ALS and dementia

2 March 2023

The most common subtypes of amyotrophic lateral sclerosis (ALS), a type of motor neurone disease, and frontotemporal dementia (FTD) is caused by a hexanucleotide expansion in C9orf72 . This leads the aberrant production of dipeptide-repeat proteins that cause toxicity and neuronal cell death. Researchers from the...

MRC Mitochondrial Biology Unit

mrc_mbu_cambridge_rgb.png

mrc_mbu_cambridge_rgb.png

The strategic mission of the MBU is to understand mitochondrial biology in health and disease, and to exploit this understanding to develop new therapies and improve human health.

Atomic details revealed of a key protein involved in the burning of fat

MBU Researchers at PInt of Science (Cambridge)

Potential new therapeutic target for inflammatory diseases

Cambridge Festival 2023

New discovery unveils how fumarate drives mitochondria to release their DNA through vesicles formation to induce innate immunity

MBU researchers help discover a new therapeutic strategy for a common form of ALS and dementia

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