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MRC Mitochondrial Biology Unit

 

The strategic mission of the MBU is to understand mitochondrial biology in health and disease, and to exploit this understanding to develop new therapies and improve human health.

 


 

Read more at: Discovery of the molecular binding/interaction sites between biguanides and complex I sheds light on the basis of metformin’s therapeutic effects, and paves the way for structure-based biguanide development

Discovery of the molecular binding/interaction sites between biguanides and complex I sheds light on the basis of metformin’s therapeutic effects, and paves the way for structure-based biguanide development

24 January 2023

The results of a study from Professor Judy Hirst , Dr Hannah Bridges and co-workers in collaboration with McGill University and ImmunoMet Therapeutics Inc. have been published in Science . Mitochondrial respiratory complex I is a major proposed cellular target enzyme of the anti-diabetic metformin, and for related...


Read more at: AMPK-dependent phosphorylation of MTFR1L regulates mitochondrial morphology

AMPK-dependent phosphorylation of MTFR1L regulates mitochondrial morphology

20 December 2022

Mitochondria are dynamic organelles that undergo membrane remodeling events in response to metabolic alterations to generate an adequate mitochondrial network. These dynamic shape transitions are regulated by cycles of fusion and fission events and are critical to maintain cellular homeostasis. A research article published...


Read more at: ISAC/M 2023: Widening Participation Programme for Cambridgeshire based Year 12 Students

ISAC/M 2023: Widening Participation Programme for Cambridgeshire based Year 12 Students

19 December 2022

The ISAC/M Programme : Inspiring Scientists at the Cambridge Institute for Medical Research and the MRC Mitochondrial Biology Unit. A free, widening participation programme for Cambridgeshire-based Year 12 students (16+) at the Cambridge Institute for Medical Research (CIMR) and MRC Mitochondrial Biology Unit (MBU), in...


Read more at: MitoKO – a library of base editors for the precise ablation of every mtDNA protein-coding gene in the mouse mitochondrial genome

MitoKO – a library of base editors for the precise ablation of every mtDNA protein-coding gene in the mouse mitochondrial genome

5 December 2022

The development of curative treatments for mitochondrial diseases, which are often caused by mutations in mitochondrial DNA (mtDNA) that impair energy metabolism and other aspects of cellular homoeostasis, is hindered by an incomplete understanding of the underlying biology and a scarcity of cellular and animal models. Dr...


Read more at: RAREfest 2022

RAREfest 2022

29 November 2022

On Saturday, 26 November 2022 MBU scientists participated in RAREfest - a n award-winning festival that is as UNIQUE as the people it champions. Featuring the brightest minds in research, innovators of life-changing technologies, pioneers in treatments, and those living with rare conditions. The Guildhall was an excellent...


Read more at: Visit by Students from Cambridge Regional College

Visit by Students from Cambridge Regional College

29 November 2022

On Monday, 21 November 2022, we hosted a visit by eleven A Level students from Cambridge Regional College, who were accompanied by two of their tutors. During the visit, there was a talk on the theme "Biology Masterclass". The "Meet the Scientsts" session gave our visitors an opportunity to talk to MBU scientists, as well...