skip to content

MRC Mitochondrial Biology Unit


Professor David Drew, Stockholm University

"The Wonders of Small Molecule Transport"

Solute Carrier (SLC) transporters mediate the translocation of substrates across membranes and after GPCRs represent the second-largest fraction of the human membrane proteome. SLC transporters are critical to cell homeostasis, which is reflected in the fact that more than a quarter of them are associated with Mendelian disease. Despite a few exceptions, however, they have been under-utilized as drug targets and our mechanistic understanding has been hampered due to technical difficulties in working with them. Here, I will present our multidisciplinary approach that has revealed important insights into the mechanism of SLC2 (GLUT) and SLC9 (Na+/H+ exchanger) transporter families that are important for our cells to utilize glucose as an energy source, and for the regulation cytoplasmic and organellar pH. I will also present our most recent biochemical and structural insights into ADP/ATP exchanger belonging to the SLC35 (nucleotide-sugar) family, which is essential for the uptake of ATP into ER and Golgi organelles for a number of biological processes, such as protein-folding.

Wednesday, 15 February, 2023 - 15:00
Event location: 
MRC MBU, Level 7 Lecture Theatre, The Keith Peters Building, CB2 0XY