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MRC Mitochondrial Biology Unit


In a letter published in Nature Cardiovascular Research, Professor Mike Murphy and collaborators report on a study led by Richard Jones and supervised jointly by Sanjay K Prasad (Royal Brompton and Harefield Hospitals, Guy’s and St. Thomas’ NHS Foundation Trust, London, UK) and Mike Murphy (MBU, Cambridge).

Recurrent myocardial ischemia can lead to left ventricular (LV) dysfunction in patients with coronary artery disease (CAD). In this observational cohort study, the authors assessed chronic metabolomic and transcriptomic adaptations within LV myocardium of patients undergoing coronary artery bypass grafting. During surgery, paired transmural LV biopsies were acquired on the beating heart from regions with and without evidence of inducible ischemia on preoperative stress perfusion cardiovascular magnetic resonance. The results suggest - that the viable myocardium of patients with CAD is energetically disrupted, despite upregulation of OXPHOS pathways. Surprisingly, there were no large differences between areas of myocardium with or without inducible ischemia.

Full publication reference:

Jones, R.E., Gruszczyk, A.V., Schmidt, C. et al.
Assessment of left ventricular tissue mitochondrial bioenergetics in patients with stable coronary artery disease.
Nat Cardiovasc Res (2023).