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MRC Mitochondrial Biology Unit

 
Read more at: Baking it Green for World Mitochondrial Disease Week

Baking it Green for World Mitochondrial Disease Week

20 September 2022

World Mitochondrial Disease Week runs from 18-24 September this year. A collaborative "Bake it Green" event is being held between members of the MBU and MitoCamb . We are contributing green cookies, cakes or healthy green options for exhibit and photo sessions....and, of course, for tasting! Daily images will be uploaded...


Read more at: Research grant awarded to Michal Minczuk and collaborators

Research grant awarded to Michal Minczuk and collaborators

6 September 2022

Congratulations to Michal Minczuk, Pedro Pinheiro and their collaborators, who have been awarded a grant to continue their research on maternally inherited Leigh syndrome (MILS). Cure ATP6 (a Rare Village Foundation Fund) and Cure Mito Foundation are excited to announce the collaboration between the groups of Dr. Michal...


Read more at: Ischemia-Selective Cardioprotection by Malonate for Ischemia/Reperfusion Injury

Ischemia-Selective Cardioprotection by Malonate for Ischemia/Reperfusion Injury

2 September 2022

A collaborative research study led by Professors Mike Murphy (MBU) and Thomas Krieg ( Experimental Medicine and Immunotherapeutics [EMIT] ) has been published in Circulation Research and is the subject of an Editorial comment . The mitochondrial metabolite succinate drives the ischemia/reperfusion (IR) injury occurring in...


Read more at: Camila Cimadamore-Werthein awarded EMBO Poster Prize

Camila Cimadamore-Werthein awarded EMBO Poster Prize

2 September 2022

Congratulations to Camila Cimadamore-Werthein, who was awarded a poster prize at the recent EMBO Workshop on Membrane transporters as essential elements of cellular function and homeostasis . Camila's poster is entitled, The human mitochondrial ADP/ATP carrier operates by a ping-pong kinetic mechanism and represents the...


Read more at: Early data presented at The Champ Foundation's 3rd Pearson Syndrome Conference

Early data presented at The Champ Foundation's 3rd Pearson Syndrome Conference

25 July 2022

On Saturday, 9 July 2022, Drs Michal Minczuk, leader of the MBU's Mitochondrial Genetics research group and Pedro Silva-Pinheiro, postdoctoral researcher in this group, attended The Champ Foundation's 3rd Pearson Syndrome Conference at Mitochondrial Medicine Center, Children’s Hospital of Philadelphia (CHOP) . Pearson...


Read more at: Reducing pdzd8-mediated MERCs in vivo using Drosophila slows age-associated decline in locomotor activity

Reducing pdzd8-mediated MERCs in vivo using Drosophila slows age-associated decline in locomotor activity

15 July 2022

Mitochondria-endoplasmic reticulum (ER) contact sites (MERCs) orchestrate many important cellular functions including regulating mitochondrial quality control through mitophagy and mediating mitochondrial calcium uptake. In a new paper from the Mitochondrial Neurodegeneration group , Dr Victoria Hewitt , with other members...


Read more at: Identification of the substrate binding mechanism of the mitochondrial ADP/ATP carrier

Identification of the substrate binding mechanism of the mitochondrial ADP/ATP carrier

28 June 2022

The results of a research study carried out by members of the MBU's group on Mitochondrial Transport Processes , published in Nature Communications , has identified the substrate binding mechanism of the ADP/ATP carrier, also called adenine nucleotide translocase. These transport proteins have unique features that enable...


Read more at: Congratulations to Professor Patrick Chinnery FRCP FMedSci

Congratulations to Professor Patrick Chinnery FRCP FMedSci

28 June 2022

Professor Patrick Chinnery has been awarded The Worshipful Society of Apothecaries ' most prestigious award - The Galen Medal in Therapeutics. The Medal is awarded in recognition of valuable services or contributions to the science of therapeutics. It has been awarded to Patrick for his work developing treatments for...


Read more at: Mike Murphy collaborates to propose new guidelines for measuring ROS and oxidative damage

Mike Murphy collaborates to propose new guidelines for measuring ROS and oxidative damage

27 June 2022

In a consensus statement published today in Nature Metabolism , Professor Mike Murphy and collaborative experts from across the globe illuminate problems that can arise with many commonly used approaches for measurement of ROS and oxidative damage, and propose guidelines for best practice. Multiple roles of reactive oxygen...


Read more at: Michal Minczuk's research highlighted in The Guardian

Michal Minczuk's research highlighted in The Guardian

27 June 2022

In an article published in The Guardian (The Observer - Medical Science) on Sunday, 26 June 2022, Dr David Cox highlights the research undertaken at the MBU by Dr Michal Minczuk and his colleagues, particularly in the areas of mitochondrial diseases where mutant mtDNA is genetically inherited.