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MRC Mitochondrial Biology Unit

 
Read more at: Inaugural Citrin Foundation Symposium

Inaugural Citrin Foundation Symposium

16 December 2019

Group leader Professor Edmund Kunji and Dr Sotiria Tavoulari, both in the MBU Mitochondrial Carriers research group, attended the Inaugural Citrin Foundation Global Research Symposium on the 11th and 12th of November in Singapore. They are funded by the Citrin Foundation to characterise the molecular properties of the...


Read more at: Cambridge Science Festival 2020

Cambridge Science Festival 2020

9 December 2019

On Sunday, 22 March 2020, the MBU will be showcasing its science at the Cambridge Science Festival event on the Cambridge Biomedical Campus. Activities will include games, movies, hands-on activities and our scientists will be available to talk to visitors about life in the laboratory. This event was subsequently cancelled...


Read more at: Visit by Sixth Form Students

Visit by Sixth Form Students

9 December 2019

We recently hosted a visit by sixth form students from Cambridgeshire. Martin gave his excellent Biology Masterclass, Ana hosted a visit to the fly laboratory and Professor Sir John Walker explained the stucture of ATP synthase with the help of our Lego model! The students met with a number of MBU members, including early...


Read more at: Mitochondrial gene therapy - with the Lily Foundation

Mitochondrial gene therapy - with the Lily Foundation

22 November 2019

The Lily Foundation is sponsoring a full PhD fellowship allowing further research into the delivery of therapeutic proteins into muscle and brain tissues in a murine model of mitochondrial disease, which will serve as vital information in pre-clinical trials. This work is being carried out in our Mitochondrial Genetics...


Read more at: Big Biology Day 2019

Big Biology Day 2019

9 October 2019

Great fun was had on Saturday, 5 October when members of the MBU took various activities to Hills Road Sixth Form College for Big Biology Day 2019. The event was attended by visitors of all ages, who tried out our new Mito-gami activity, along with our "Destroying Mutant Mitochondrial DNA" game and mtDNA sequencing puzzles...


Read more at: Succinate accumulation drives ischaemia-reperfusion injury during organ transplantation

Succinate accumulation drives ischaemia-reperfusion injury during organ transplantation

26 September 2019

An interdisciplinary study led by Mike Murphy of the MBU and the Department of Medicine, and Kourosh Saeb-Parsy of the Department of Surgery has just been published in Nature Metabolism . In collaboration with colleagues in the MRC Cancer Unit and the University of Glasgow , they were interested in finding out why organs...


Read more at: Reaching out to Lowestoft and Beccles

Reaching out to Lowestoft and Beccles

20 September 2019

On 18 and 19 September 2019, Dr Martin King visited three schools and a sixth form college in Suffolk, giving a 'masterclass' on mitochondrial biology, an overview of life at university (and Cambridge!) and helping with university interview techniques. This tour was arranged in collaboration with Kathryn Singleton, School...


Read more at: Global Mitochondrial Disease Awareness Week

Global Mitochondrial Disease Awareness Week

16 September 2019

This week, 15-21 September 2019, is Mitochondrial Disease Awareness Week. Around the world Global Mitochondrial Disease Awareness Week (GMDAW) will be marked with educational, fundraising and advocacy efforts designed to raise awareness about mitochondrial disease (mito). The MBU's website will follow a green theme for the...


Read more at: Development of an alternative MtDNA mutator model for APOBEC1

Development of an alternative MtDNA mutator model for APOBEC1

25 July 2019

Stochastic mutations in the mitochondrial genome (mtDNA) have been linked to many diseases, and their accumulation has been proposed to act as a driving force in the ageing process itself. For the past 15 years the main animal model used to study this phenomenon has been the ‘mutator’ mouse, harbouring a proofreading...


Read more at: Structure of F1-ATPase from the obligate anaerobe Fusobacterium nucleatum

Structure of F1-ATPase from the obligate anaerobe Fusobacterium nucleatum

26 June 2019

Adenosine triphosphate (ATP), the fuel of life, is produced by a molecular machine consisting of two motors linked by a rotor. One generates rotation by consuming energy derived from oxidative metabolism or photosynthesis; the other uses energy transmitted by the rotor to make ATP from adenosine diphosphate and phosphate...