News

Interface mobility between monomers in dimeric bovine ATP synthase participates in the ultrastructure of inner mitochondrial membranes

25 February 2021

In a research article published in Proceedings of the National Academy of Sciences, USA , Tobias Spikes, Martin Montgomery and John Walker have shown how the mobility in the interfaces between monomers in dimeric bovine ATP synthase participates in forming the characteristic and ever-changing ultrastructure of inner...

The Cambridge Festival 2021

11 February 2021

The Cambridge Festival is taking place online this year - from 26 March until 4 April. MBU We are sorry, but our "MBU Challenge" game is not yet ready to share. We have two existing computer games to share on 4 April: The Battle for the Mitochondrion! The Mitochondrion: Heteroplasmy There is a bug in Heteroplasmy, but it...

Structural insights into the role of mitochondrial complex I in heart attack

29 January 2021

A collaborative research project led by Professor Judy Hirst at the MBU, working with Mike Murphy (MBU) and Thomas Krieg (Medicine), provides important new insights into the cell damage that occurs during heart attacks. This work, published in Nature Communications with MBU PhD student Zhan Yin as first author, focuses on...

Review inspires image for Journal cover

21 January 2021

Inspired by a collaborative review by James Stewart (Cologne) and Patrick Chinnery , published in September 2020, Nature Reviews Genetics has chosen an image designed by Patrick Morgan for its February 2021 cover. The review entitled, “Extreme heterogeneity of human mitochondrial DNA from organelles to populations” casts...

Michal Minczuk collaborates with Venki Ramakrishnan on ribosomal rescue in human mitochondria

27 November 2020

Venki Ramakrishnan (MRC LMB) and his research group, in a collaboration with Michal Minczuk , obtained cryo-EM structures of mitorobosomes purified from human cell line known to have a high propensity for ribosome stalling. This cellular model was generated by Michal’s group as a part of the PhD project of Sarah Pearce ...

Milo Keynes Prize awarded to Pedro Guiomar

24 November 2020

Pedro Guiomar has been awarded the Milo Keynes Prize for the academic year 2019–20, in recognition of the very high quality of his PhD thesis entitled “The role of RNA modifications in mitochondrial translation”. The Milo Keynes Prize is awarded by the Degree Committee for the Faculties of Clinical Medicine and Veterinary...

Professor Judy Hirst appointed Director of the MRC MBU

23 November 2020

From the Regius Professor of Physic and Dr Rob Buckle, Chief Science Officer at the MRC On behalf of the Medical Research Council (MRC) and the University of Cambridge, we are delighted to announce that Professor Judy Hirst has been appointed as the next Director of the MRC Mitochondrial Biology Unit. Judy has been the...

World Mitochondrial Disease Week

13 September 2020

mito-facts6.jpg This week, 13-19 September 2020 is World Mitochondrial Disease Week . An initiative of International Mito Patients (IMP), World Mitochondrial Disease Week raises awareness of mitochondrial disease (mito) on a global scale through educational, fundraising and advocacy activities. As we have not been able to...

John Walker's group solves the structure of the dimeric ATP synthase from bovine mitochondria at atomic resolution

9 September 2020

Tobias Spikes, Martin Montgomery and John Walker have solved the atomic resolution structure of dimeric ATP synthase from bovine mitochondria by cryo-electron microscopy. The ATP synthases are complex molecular machines embedded in the inner membranes of mitochondria where they produce almost all the ATP required to...

MBU volunteers involved in Covid-19 testing

7 September 2020

Volunteers from the MBU have been involved in the collaborative COVID-19 testing operation, based at the Cambridge Testing Centre in Partnership with AstraZeneca and GSK. Charis Goodyear has been talking to volunteers from across the Biomedical Campus, who joined the testing team when they were not able to carry out their...

Interface mobility between monomers in dimeric bovine ATP synthase participates in the ultrastructure of inner mitochondrial membranes

The Cambridge Festival 2021

Structural insights into the role of mitochondrial complex I in heart attack

Review inspires image for Journal cover

Michal Minczuk collaborates with Venki Ramakrishnan on ribosomal rescue in human mitochondria

Milo Keynes Prize awarded to Pedro Guiomar

Professor Judy Hirst appointed Director of the MRC MBU

World Mitochondrial Disease Week

John Walker's group solves the structure of the dimeric ATP synthase from bovine mitochondria at atomic resolution

MBU volunteers involved in Covid-19 testing

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