News

Collaboration with Nigerian researchers evaluating the neuroprotective potential of natural products

28 March 2022

As an alternative to expensive pharmaceuticals, there is broad interest in the developing world to evaluate the therapeutic potential of natural compounds for widespread, debilitating diseases. As part of our ongoing effort to engage with a broader scientific community, Dr Alex Whitworth (Mitochondrial Neurodegeneration)...

Nature Reviews Genetics - featured article for April

22 March 2022

The Editorial Team at Nature Reviews Genetics has chosen the recent review by Pedro Silva-Pinheiro and Michal Minczuk as the Journal's featured article for the April issue . The review, entitled The potential of mitochondrial genome engineering , reflects on the past, present and future of mitochondrial genome engineering...

Identification of a key checkpoint during mitoribosomal large subunit (mtLSU) assembly

17 February 2022

In a collaborative research article published today in Nature Communications , Pedro Rebelo-Guiomar and MBU colleagues from the research groups of Drs Michal Minczuk and Alex Whitworth at the MBU report the identification of a key checkpoint during mtLSU assembly, which is essential to maintaining mitochondrial homeostasis...

Potential for gene-editing to tackle mitochondria disorders

8 February 2022

A research article published today (8 February 2022) in Nature Communications describes how Pedro Silva-Pinheiro and colleagues from the Mitochondrial Genetics Group led by Dr Michal Minczuk at the MBU were able to edit the mitochondrial DNA of live mice. The researchers used a biological tool, known as a mitochondrial...

Professors Patrick Chinnery and John Walker to deliver the XIII Oon Lecture

25 January 2022

Professors Patrick Chinnery and John Walker will deliver the XIII Oon Lecture, "Mitochondria: from molecules to medicine" at Downing College (Howard Theatre) at 6.00 pm on Tuesday, 15 February 2022. The lecture was streamed live and the recording is available on YouTube (21 February).

Biology Masterclass at Lowestoft

17 December 2021

After a two-year break due to Covid contingencies, Dr Martin King recently delivered his Biology Masterclass to students of Lowestoft Sixth Form College (East Coast College). Martin’s presentation was delivered under social distancing guidelines, which made some communications difficult, but the feedback reflects a...

Single-molecule mitochondrial DNA sequencing shows no evidence of CpG methylation in human cells and tissues

14 December 2021

The results of a research study carried out by Iacopo Bicci and Claudia Calabrese in Professor Patrick Chinnery’s laboratory have been published in Nucleic Acids Research . Cytosine methylation is an epigenetic modification of nuclear DNA (nDNA) that can regulate gene expression during development and throughout life, but...

Reflection on the past, present and future of mitochondrial genome engineering

8 December 2021

In a review published in Nature Reviews Genetics, entitled The potential of mitochondrial genome engineering , Pedro Silva-Pinheiro and Michal Minczuk reflect on the past, present and future of mitochondrial genome engineering. Mitochondria are subject to unique genetic control by both nuclear DNA and their own genome...

Structure of ATP synthase from Mycobacterium smegmatis provides targets for treating tuberculosis

16 November 2021

A research study led by Professor John Walker has been published in Proceedings of the National Acadmy of Sciences of the United States of America . As the world tackles the COVID-19 pandemic, other wide-spread infectious diseases, including tuberculosis (TB), take their toll on mankind, and those with TB are more likely...

Whole genome sequencing from a single blood test detects 31% more cases of rare genetic disorders than standard tests

4 November 2021

The results of a research study led by Professor Patrick Chinnery , in collaboration with scientists from the MRC MBU, and the Departments of Clinical Neurosciences and Medical Genetics, have been published in the British Medical Journal . In total, 345 participants – aged 0 to 92 with a median age of 25 years – had their...

Collaboration with Nigerian researchers evaluating the neuroprotective potential of natural products

Nature Reviews Genetics - featured article for April

Identification of a key checkpoint during mitoribosomal large subunit (mtLSU) assembly

Potential for gene-editing to tackle mitochondria disorders

Professors Patrick Chinnery and John Walker to deliver the XIII Oon Lecture

Biology Masterclass at Lowestoft

Single-molecule mitochondrial DNA sequencing shows no evidence of CpG methylation in human cells and tissues

Reflection on the past, present and future of mitochondrial genome engineering

Structure of ATP synthase from Mycobacterium smegmatis provides targets for treating tuberculosis

Whole genome sequencing from a single blood test detects 31% more cases of rare genetic disorders than standard tests

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