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Whitworth group research identifies an important PINK1/Parkin mitophagy regulator

20 February 2024

Mitochondrial dysfunction is a key pathogenic driver of neurodegenerative diseases such as Parkinson’s disease (PD). Extensive research has established that the PD-linked genes, PINK1 and Parkin, are important factors mediating the degradation of dysfunctional mitochondria via mitophagy. Hence, there is intense interest in...

Display on "Mitochondrial Energy" at the Irish Patchwork Society Exhibition

14 February 2024

Mary Heseltine is a retired data analyst who now concentrates her interests in textiles. Mary contributed to a textile exhibition in connection with the celebration of the 1500 th anniversary of the birth of St Brigid, which opened in Dublin on 1 February 2024, in conjunction with the (new) early Spring Festival Bank...

A break in mitochondrial endosymbiosis as a basis for inflammatory diseases

8 February 2024

A review co-authored by Professor Mike Murphy has been published in Nature . Mitochondria retain bacterial traits due to their endosymbiotic origin, but host cells do not recognize them as foreign because the organelles are sequestered. However, the regulated release of mitochondrial factors into the cytosol can trigger...

Whitworth group research links mitochondrial calcium disruptions to multiple neurodegenerative diseases

23 January 2024

Mitochondrial dysfunction and calcium dysregulation are commonly observed in multiple neurodegenerative diseases, but mechanisms linking these are poorly understood in the context of neurodegeneration. In a study led by Dr Alex Whitworth (MRC Mitochondrial Biology Unit) and recently published in Cell Reports, Twyning et al...

Research from the Minczuk and Prudent Groups on the cover of Nucleic Acids Research

30 November 2023

A method paper describing a tool for automated, single-cell mitochondrial foci quantification and analysis- mtFociCounter - developed by Timo Rey, a former postdoc in the Minczuk Group , in collaboration with Luis Carlos Tábara, a postdoc in the Prudent Group , has been highlighted on the cover of the current issue of...

Current Opinion in Structural Biology - Best Paper Award for Researchers in Judy Hirst's Group

13 November 2023

A review authored by members of Professor Judy Hirst’s research group has been announced as one of Current Opinion in Structural Biology ’s best papers of 2022. " Making the leap from structure to mechanism: are the open states of mammalian complex I identified by cryoEM resting states or catalytic intermediates? " by...

Big Biology Day 2023

17 October 2023

On Saturday, 14 October 2023, fifteen members of the MBU participated in the Big Biology Day, held at Hills Road Sixth Form College. Using hands on, interactive activities, MBU members (senior and junior scientists) showcased the Unit's research on mitochondria, giving explanations and career advice. Our activities this...

Portrait of John Walker unveiled at Sidney Sussex College

5 October 2023

On Wednesday, 4 October, members of the MBU and the LMB past and present, along with Fellows of Sidney Sussex College, members of John's family and friends, attended the unveiling ceremony of the portrait, by Frances Bell , of Professor Sir John Walker . Of course, Frances Bell was there too. Frances is a member of the...

PHAsT upscales its eco-friendly bacterial fermentation at the MBU

4 October 2023

Last week, supported by funding from a UKRI Impact Accelerator Grant proposed by Ipsita Roy and David Gregory, members of PHAsT visited the MBU and upscaled its fermentation PHA process to the 100L scale - ending up with fantastic yields! Our Fermenter Facility Supervisor, Shane Palmer , provided significant support...

Professor Patrick Chinnery appointed Executive Chair of the Medical Research Council

22 August 2023

Congratulations to Professor Patrick Chinnery , who has been appointed Executive Chair of the Medical Research Council. Full details are available on the University of Cambridge and Medical Research Council websites.

Whitworth group research identifies an important PINK1/Parkin mitophagy regulator

Display on "Mitochondrial Energy" at the Irish Patchwork Society Exhibition

A break in mitochondrial endosymbiosis as a basis for inflammatory diseases

Whitworth group research links mitochondrial calcium disruptions to multiple neurodegenerative diseases

Research from the Minczuk and Prudent Groups on the cover of Nucleic Acids Research

Current Opinion in Structural Biology - Best Paper Award for Researchers in Judy Hirst's Group

Big Biology Day 2023

Portrait of John Walker unveiled at Sidney Sussex College

PHAsT upscales its eco-friendly bacterial fermentation at the MBU

Professor Patrick Chinnery appointed Executive Chair of the Medical Research Council

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